Antineutrophil cytoplasmic antibody (ANCA)–related vasculitis, like Wegener's granulomatosis and microscopic polyangiitis, can be a multisystem autoimmune syndrome characterized by vasculitis predominantly influencing microscopic vessels and circulating autoantibodies to neutrophil cytoplasmic antigens. Renal involvement happens in 70% of afflicted sufferers which is manifested as swiftly progressive glomerulonephritis with pauci-immune necrotizing, crescentic glomerulonephritis on biopsy.
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